6I9C

Structure of the OTU domain of OTULIN G281R mutant

Summary for 6I9C

Entry DOI	10.2210/pdb6i9c/pdb
Descriptor	Ubiquitin thioesterase otulin, GLYCEROL, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	met1-specific deubiquitinase, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	31668.79
Authors	Damgaard, R.B.,Elliott, P.R.,Swatek, K.N.,Maher, E.R.,Stepensky, P.,Elpeleg, O.,Komander, D.,Berkun, Y. (deposition date: 2018-11-22, release date: 2019-03-06, Last modification date: 2019-03-20)
Primary citation	Damgaard, R.B.,Elliott, P.R.,Swatek, K.N.,Maher, E.R.,Stepensky, P.,Elpeleg, O.,Komander, D.,Berkun, Y. OTULIN deficiency in ORAS causes cell type-specific LUBAC degradation, dysregulated TNF signalling and cell death. Embo Mol Med, 11:-, 2019 Cited by PubMed: 30804083 DOI: 10.15252/emmm.201809324 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.77 Å)

Structure validation