6I3Z

Fab fragment of an antibody selective for wild-type alpha-1-antitrypsin in complex with its antigen

Summary for 6I3Z

• Entry DOI: 10.2210/pdb6i3z/pdb
• Related: 6IO1
• Descriptor: Alpha-1-antitrypsin, Fab 2H2 heavy chain, Fab 2H2 light chain, ... (7 entities in total)
• Functional Keywords: antibody fragment, antitrypsin binding, diagnostic, monoclonal, protein binding, selective, wild-type, glu342, e342
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 91886.18

Authors

Laffranchi, M.,Elliston, E.L.K.,Miranda, E.,Perez, J.,Jagger, A.M.,Fra, A.,Lomas, D.A.,Irving, J.A. (deposition date: 2018-11-08, release date: 2019-11-20, Last modification date: 2024-01-24)

• Primary citation: Laffranchi, M.,Elliston, E.L.,Miranda, E.,Perez, J.,Ronzoni, R.,Jagger, A.M.,Heyer-Chauhan, N.,Brantly, M.L.,Fra, A.,Lomas, D.A.,Irving, J.A.; Intrahepatic heteropolymerization of M and Z alpha-1-antitrypsin.; JCI Insight, 5:-, 2020; PubMed: 32699193; DOI: 10.1172/jci.insight.135459

Experimental method

X-RAY DIFFRACTION (3.1 Å)