6HZN

Crystal structure of human dermatan sulfate epimerase 1

Summary for 6HZN

• Entry DOI: 10.2210/pdb6hzn/pdb
• Descriptor: Dermatan-sulfate epimerase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: epimerase, golgi, glycosaminoglycans, chondroitin sulfate, dermatan sulfate, biosynthetic protein, isomerase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 89484.43

Authors

Hasan, M.,Unge, J.,Westergren-Thorsson, G.,Ellervik, U.,Mueller, U.,Malmstrom, A.,Tykesson, E. (deposition date: 2018-10-23, release date: 2020-01-22, Last modification date: 2020-12-16)

• Primary citation: Hasan, M.,Khakzad, H.,Happonen, L.,Sundin, A.,Unge, J.,Mueller, U.,Malmstrom, J.,Westergren-Thorsson, G.,Malmstrom, L.,Ellervik, U.,Malmstrom, A.,Tykesson, E.; The structure of human dermatan sulfate epimerase 1 emphasizes the importance of C5-epimerization of glucuronic acid in higher organisms; Chem Sci, 2020; DOI: 10.1039/D0SC05971D

Experimental method

X-RAY DIFFRACTION (2.41 Å)