6HYT

Crystal structure of DHX8 helicase domain bound to ADP at 2.3 Angstrom

Summary for 6HYT

Entry DOI	10.2210/pdb6hyt/pdb
Descriptor	ATP-dependent RNA helicase DHX8, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (8 entities in total)
Functional Keywords	helicase, splicing, rna, rna binding protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	311383.25
Authors	Felisberto-Rodrigues, C.,Thomas, J.C.,McAndrew, P.C.,Le Bihan, Y.V.,Burke, R.,Workman, P.,van Montfort, R.L.M. (deposition date: 2018-10-22, release date: 2019-08-28, Last modification date: 2024-05-15)
Primary citation	Felisberto-Rodrigues, C.,Thomas, J.C.,McAndrew, C.,Le Bihan, Y.V.,Burke, R.,Workman, P.,van Montfort, R.L.M. Structural and functional characterisation of human RNA helicase DHX8 provides insights into the mechanism of RNA-stimulated ADP release. Biochem.J., 476:2521-2543, 2019 Cited by PubMed: 31409651 DOI: 10.1042/BCJ20190383 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.33 Å)

Structure validation