6HYC
The structure of full-length human phenylalanine hydroxylase in complex with the cofactor and negative regulator tetrahydrobiopterin
Summary for 6HYC
Entry DOI | 10.2210/pdb6hyc/pdb |
Descriptor | Phenylalanine-4-hydroxylase, 5,6,7,8-TETRAHYDROBIOPTERIN (3 entities in total) |
Functional Keywords | tetrahydrobiopterin, phenylalanine hydroxylase, phenylketonuria, allostery, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 208439.37 |
Authors | Alcorlo Pages, M.,Flydal, I.M. (deposition date: 2018-10-19, release date: 2019-06-05, Last modification date: 2024-01-24) |
Primary citation | Flydal, M.I.,Alcorlo-Pages, M.,Johannessen, F.G.,Martinez-Caballero, S.,Skjærven, L.,Fernandez-Leiro, R.,Martinez, A.,Hermoso, J.A. Structure of full-length human phenylalanine hydroxylase in complex with tetrahydrobiopterin. Proc.Natl.Acad.Sci.USA, 116:11229-11234, 2019 Cited by PubMed: 31118288DOI: 10.1073/pnas.1902639116 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.18 Å) |
Structure validation
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