6HYC

The structure of full-length human phenylalanine hydroxylase in complex with the cofactor and negative regulator tetrahydrobiopterin

6HYC の概要

• エントリーDOI: 10.2210/pdb6hyc/pdb
• 分子名称: Phenylalanine-4-hydroxylase, 5,6,7,8-TETRAHYDROBIOPTERIN (3 entities in total)
• 機能のキーワード: tetrahydrobiopterin, phenylalanine hydroxylase, phenylketonuria, allostery, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 208439.37

構造登録者

Alcorlo Pages, M.,Flydal, I.M. (登録日: 2018-10-19, 公開日: 2019-06-05, 最終更新日: 2024-01-24)

• 主引用文献: Flydal, M.I.,Alcorlo-Pages, M.,Johannessen, F.G.,Martinez-Caballero, S.,Skjærven, L.,Fernandez-Leiro, R.,Martinez, A.,Hermoso, J.A.; Structure of full-length human phenylalanine hydroxylase in complex with tetrahydrobiopterin.; Proc.Natl.Acad.Sci.USA, 116:11229-11234, 2019; PubMed: 31118288; DOI: 10.1073/pnas.1902639116

実験手法

X-RAY DIFFRACTION (3.18 Å)