Yeast 20S proteasome with human beta2i (1-53) in complex with 39

Summary for 6HVV

DescriptorProteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ... (19 entities in total)
Functional Keywordsproteasome, mutant, inhibitor, binding analysis, hydrolase
Biological sourceHomo sapiens (Human)
Total number of polymer chains28
Total molecular weight732784.13
Huber, E.M.,Groll, M. (deposition date: 2018-10-11, release date: 2019-01-30, Last modification date: 2019-04-24)
Primary citation
Xin, B.T.,Huber, E.M.,de Bruin, G.,Heinemeyer, W.,Maurits, E.,Espinal, C.,Du, Y.,Janssens, M.,Weyburne, E.S.,Kisselev, A.F.,Florea, B.I.,Driessen, C.,van der Marel, G.A.,Groll, M.,Overkleeft, H.S.
Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits.
J.Med.Chem., 62:1626-1642, 2019
PubMed: 30657666 (PDB entries with the same primary citation)
DOI: 10.1021/acs.jmedchem.8b01884
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2211 0.1% 4.0% 2.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution