6HR8

HMG-CoA reductase from Methanothermococcus thermolithotrophicus in complex with NADPH at 2.9 A resolution

Summary for 6HR8

Entry DOI	10.2210/pdb6hr8/pdb
Descriptor	HMG-CoA reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION, ... (6 entities in total)
Functional Keywords	hmg-coa, mevalonate biosynthesis, statins, cholesterol biosynthesis, isoprenoids, nadph, structural rearrangement., oxidoreductase
Biological source	Methanothermococcus thermolithotrophicus DSM 2095 More
Total number of polymer chains	6
Total formula weight	285794.62
Authors	Wagner, T.,Voegeli, B.,Erb, T.J.,Shima, S. (deposition date: 2018-09-26, release date: 2019-02-13, Last modification date: 2024-01-24)
Primary citation	Vogeli, B.,Shima, S.,Erb, T.J.,Wagner, T. Crystal structure of archaeal HMG-CoA reductase: insights into structural changes of the C-terminal helix of the class-I enzyme. Febs Lett., 593:543-553, 2019 Cited by PubMed: 30702149 DOI: 10.1002/1873-3468.13331 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation