6HD4

ABL1 IN COMPLEX WITH COMPOUND 7 AND IMATINIB (STI-571)

Summary for 6HD4

Entry DOI	10.2210/pdb6hd4/pdb
Descriptor	Tyrosine-protein kinase ABL1, GLYCEROL, CHLORIDE ION, ... (6 entities in total)
Functional Keywords	phosphotransferase, inhibitor complex, transferase
Biological source	Mus musculus (Mouse)
Total number of polymer chains	2
Total formula weight	69492.59
Authors	Cowan-Jacob, S.W. (deposition date: 2018-08-17, release date: 2018-10-24, Last modification date: 2024-01-17)
Primary citation	Schoepfer, J.,Jahnke, W.,Berellini, G.,Buonamici, S.,Cotesta, S.,Cowan-Jacob, S.W.,Dodd, S.,Drueckes, P.,Fabbro, D.,Gabriel, T.,Groell, J.M.,Grotzfeld, R.M.,Hassan, A.Q.,Henry, C.,Iyer, V.,Jones, D.,Lombardo, F.,Loo, A.,Manley, P.W.,Pelle, X.,Rummel, G.,Salem, B.,Warmuth, M.,Wylie, A.A.,Zoller, T.,Marzinzik, A.L.,Furet, P. Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1. J. Med. Chem., 61:8120-8135, 2018 Cited by PubMed: 30137981 DOI: 10.1021/acs.jmedchem.8b01040 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.03 Å)

Structure validation