6HD4
ABL1 IN COMPLEX WITH COMPOUND 7 AND IMATINIB (STI-571)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004713 | molecular_function | protein tyrosine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004713 | molecular_function | protein tyrosine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue GOL A 601 |
| Chain | Residue |
| A | TYR339 |
| A | HOH818 |
| A | HOH867 |
| A | TYR345 |
| A | GLU353 |
| A | TYR432 |
| A | ASN498 |
| A | PRO499 |
| A | HOH707 |
| A | HOH737 |
| A | HOH779 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 602 |
| Chain | Residue |
| A | ILE379 |
| A | HOH900 |
| A | HOH938 |
| site_id | AC3 |
| Number of Residues | 20 |
| Details | binding site for residue FYW A 603 |
| Chain | Residue |
| A | ARG351 |
| A | ALA356 |
| A | LEU359 |
| A | LEU360 |
| A | ALA363 |
| A | LEU448 |
| A | ILE451 |
| A | ALA452 |
| A | THR453 |
| A | GLU481 |
| A | PRO484 |
| A | VAL487 |
| A | PHE512 |
| A | ILE521 |
| A | VAL525 |
| A | LEU529 |
| A | HOH706 |
| A | HOH746 |
| A | HOH795 |
| A | HOH849 |
| site_id | AC4 |
| Number of Residues | 18 |
| Details | binding site for residue STI A 604 |
| Chain | Residue |
| A | VAL275 |
| A | ALA288 |
| A | LYS290 |
| A | GLU305 |
| A | MET309 |
| A | ILE312 |
| A | VAL318 |
| A | ILE332 |
| A | THR334 |
| A | PHE336 |
| A | MET337 |
| A | ILE379 |
| A | HIS380 |
| A | LEU389 |
| A | ALA399 |
| A | ASP400 |
| A | PHE401 |
| A | HOH854 |
| site_id | AC5 |
| Number of Residues | 18 |
| Details | binding site for residue FYW B 601 |
| Chain | Residue |
| B | ARG351 |
| B | ALA356 |
| B | LEU359 |
| B | LEU360 |
| B | LEU448 |
| B | ILE451 |
| B | ALA452 |
| B | THR453 |
| B | TYR454 |
| B | MET456 |
| B | GLU481 |
| B | VAL487 |
| B | PHE512 |
| B | ILE521 |
| B | VAL525 |
| B | LEU529 |
| B | HOH721 |
| B | HOH759 |
| site_id | AC6 |
| Number of Residues | 17 |
| Details | binding site for residue STI B 602 |
| Chain | Residue |
| B | VAL275 |
| B | ALA288 |
| B | LYS290 |
| B | GLU305 |
| B | MET309 |
| B | ILE312 |
| B | VAL318 |
| B | ILE332 |
| B | THR334 |
| B | PHE336 |
| B | MET337 |
| B | ILE379 |
| B | HIS380 |
| B | ALA399 |
| B | ASP400 |
| B | PHE401 |
| B | HOH783 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGGGQYGEVYeGvwkkyslt..........VAVK |
| Chain | Residue | Details |
| A | LEU267-LYS290 |
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FIHrDLAARNCLV |
| Chain | Residue | Details |
| A | PHE378-VAL390 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 48 |
| Details | Motif: {"description":"Kinase activation loop"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 28 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P42684","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P00519","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine; by autocatalysis and SRC-type Tyr-kinases","evidences":[{"source":"PubMed","id":"10988075","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12748290","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"9109492","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
