6HD4
ABL1 IN COMPLEX WITH COMPOUND 7 AND IMATINIB (STI-571)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosine-protein kinase ABL1 | polymer | 293 | 33743.5 | 2 | UniProt (P00520) Pfam (PF07714) | Mus musculus (Mouse) | Abelson murine leukemia viral oncogene homolog 1,Abelson tyrosine-protein kinase 1,Proto-oncogene c-Abl,p150 |
| 2 | C (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 3 | D (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | E, G (A, B) | 6-[(3~{R})-3-oxidanylpyrrolidin-1-yl]-5-pyrimidin-5-yl-~{N}-[4-(trifluoromethyloxy)phenyl]pyridine-3-carboxamide | non-polymer | 445.4 | 2 | Chemie (FYW) | |||
| 5 | F, H (A, B) | 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE | non-polymer | 493.6 | 2 | Chemie (STI) | |||
| 6 | I, J (A, B) | water | water | 18.0 | 384 | Chemie (HOH) |
Sequence modifications
A, B: 248 - 534 (UniProt: P00520)
| PDB | External Database | Details |
|---|---|---|
| Gly 242 | - | expression tag |
| Ala 243 | - | expression tag |
| Met 244 | - | expression tag |
| Asp 245 | - | expression tag |
| Pro 246 | - | expression tag |
| Ser 247 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 67487.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2005.5 | |
| All* | Total formula weight | 69492.6 |
