6GZY

HOIP-fragment5 complex

Summary for 6GZY

Entry DOI	10.2210/pdb6gzy/pdb
Descriptor	E3 ubiquitin-protein ligase RNF31, methyl 4-[(2-oxidanylidene-1,5,6,7-tetrahydrocyclopenta[b]pyridin-3-yl)carbonylamino]butanoate, ZINC ION, ... (8 entities in total)
Functional Keywords	ubiquitin ligase, e3, inhibitor complex, ligase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	52396.06
Authors	Johansson, H.,Tsai, Y.C.I.,Fantom, K.,Chung, C.W.,Martino, L.,House, D.,Rittinger, K. (deposition date: 2018-07-05, release date: 2019-01-30, Last modification date: 2024-01-17)
Primary citation	Johansson, H.,Isabella Tsai, Y.C.,Fantom, K.,Chung, C.W.,Kumper, S.,Martino, L.,Thomas, D.A.,Eberl, H.C.,Muelbaier, M.,House, D.,Rittinger, K. Fragment-Based Covalent Ligand Screening Enables Rapid Discovery of Inhibitors for the RBR E3 Ubiquitin Ligase HOIP. J. Am. Chem. Soc., 141:2703-2712, 2019 Cited by PubMed: 30657686 DOI: 10.1021/jacs.8b13193 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation