Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0071797 | cellular_component | LUBAC complex |
| B | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0071797 | cellular_component | LUBAC complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue FHH A 4001 |
| Chain | Residue |
| A | ILE869 |
| A | SER899 |
| A | HOH4119 |
| A | HOH4143 |
| A | TYR878 |
| A | LEU880 |
| A | ALA881 |
| A | CYS885 |
| A | HIS887 |
| A | PHE888 |
| A | HIS889 |
| A | THR891 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 4002 |
| Chain | Residue |
| A | CYS871 |
| A | CYS874 |
| A | CYS890 |
| A | CYS893 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 4003 |
| Chain | Residue |
| A | CYS898 |
| A | CYS901 |
| A | HIS926 |
| A | CYS930 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 4004 |
| Chain | Residue |
| A | CYS911 |
| A | CYS916 |
| A | HIS923 |
| A | HIS925 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 4005 |
| Chain | Residue |
| A | CYS969 |
| A | CYS986 |
| A | CYS998 |
| A | HIS1001 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 4006 |
| Chain | Residue |
| A | ASN903 |
| A | PRO927 |
| A | GLY1064 |
| A | GLN1065 |
| A | SER1066 |
| A | HOH4124 |
| A | HOH4138 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 4007 |
| Chain | Residue |
| A | THR938 |
| A | ALA939 |
| A | TYR994 |
| A | GLN999 |
| A | LYS1003 |
| A | HOH4104 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 4008 |
| Chain | Residue |
| A | ASN867 |
| A | ARG1070 |
| A | ARG1071 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 4009 |
| Chain | Residue |
| A | LYS873 |
| A | HOH4103 |
| B | LYS988 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 4010 |
| Chain | Residue |
| A | TYR1021 |
| A | GLU1025 |
| A | ARG1032 |
| A | TYR1033 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 4011 |
| Chain | Residue |
| A | ASN1011 |
| A | PRO1068 |
| A | ARG1070 |
| A | HOH4125 |
| A | HOH4140 |
| A | HOH4141 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue PGE A 4012 |
| Chain | Residue |
| A | GLN947 |
| A | ASN950 |
| A | VAL951 |
| A | MET952 |
| A | PHE953 |
| A | THR955 |
| site_id | AD4 |
| Number of Residues | 1 |
| Details | binding site for residue NA A 4013 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 4002 |
| Chain | Residue |
| B | CYS871 |
| B | CYS874 |
| B | CYS890 |
| B | CYS893 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 4003 |
| Chain | Residue |
| B | CYS898 |
| B | CYS901 |
| B | HIS926 |
| B | CYS930 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 4004 |
| Chain | Residue |
| B | CYS911 |
| B | CYS916 |
| B | HIS923 |
| B | HIS925 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 4005 |
| Chain | Residue |
| B | CYS969 |
| B | CYS986 |
| B | CYS998 |
| B | HIS1001 |
| site_id | AD9 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 B 4006 |
| Chain | Residue |
| B | ASN903 |
| B | PRO927 |
| B | GLY1064 |
| B | GLN1065 |
| B | SER1066 |
| B | NA4011 |
| B | HOH4120 |
| B | HOH4127 |
| site_id | AE1 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 4007 |
| Chain | Residue |
| B | THR938 |
| B | ALA939 |
| B | TYR994 |
| B | GLN999 |
| B | LYS1003 |
| B | HOH4105 |
| B | HOH4159 |
| site_id | AE2 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 4008 |
| Chain | Residue |
| B | ARG1070 |
| B | ARG1071 |
| B | HOH4133 |
| site_id | AE3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 4009 |
| Chain | Residue |
| B | TYR1021 |
| B | GLU1025 |
| B | ARG1032 |
| B | TYR1033 |
| B | TYR933 |
| site_id | AE4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 4010 |
| Chain | Residue |
| B | SER1008 |
| B | ASN1011 |
| B | PRO1068 |
| B | ARG1070 |
| B | HOH4103 |
| B | HOH4126 |
| site_id | AE5 |
| Number of Residues | 1 |
| Details | binding site for residue NA B 4011 |
| site_id | AE6 |
| Number of Residues | 18 |
| Details | binding site for Di-peptide FHH B 4001 and CYS B 885 |
| Chain | Residue |
| A | CYS874 |
| A | CYS893 |
| B | TYR878 |
| B | LEU880 |
| B | ALA881 |
| B | ARG882 |
| B | GLY883 |
| B | GLY884 |
| B | MET886 |
| B | HIS887 |
| B | PHE888 |
| B | HIS889 |
| B | THR891 |
| B | SER899 |
| B | GLN974 |
| B | HOH4122 |
| B | HOH4123 |
| B | HOH4145 |
Functional Information from PROSITE/UniProt
| site_id | PS00518 |
| Number of Residues | 10 |
| Details | ZF_RING_1 Zinc finger RING-type signature. CrHqFCsgCY |
| Chain | Residue | Details |
| A | CYS893-TYR902 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 60 |
| Details | Zinc finger: {"description":"RING-type 2; atypical","evidences":[{"source":"PROSITE-ProRule","id":"PRU01221","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01221","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01221","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"(Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"27572974","evidenceCode":"ECO:0000269"}]} |
