6GN7

X-ray structure of the complex between human alpha thrombin and NU172, a duplex/quadruplex 26-mer DNA aptamer, in the presence of sodium ions.

6GN7 の概要

• エントリーDOI: 10.2210/pdb6gn7/pdb
• 関連するPDBエントリー: 6EVV
• 関連するBIRD辞書のPRD_ID: PRD_000020
• 分子名称: Prothrombin, NU172, DNA (26-MER), N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: thrombin-dna, g-quadruplex, aptamer, duplex/quadruplex, hydrolase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 44046.31

構造登録者

Troisi, R.,Russo Krauss, I.,Sica, F. (登録日: 2018-05-30, 公開日: 2018-10-17, 最終更新日: 2024-01-17)

• 主引用文献: Troisi, R.,Napolitano, V.,Spiridonova, V.,Russo Krauss, I.,Sica, F.; Several structural motifs cooperate in determining the highly effective anti-thrombin activity of NU172 aptamer.; Nucleic Acids Res., 46:12177-12185, 2018; PubMed: 30357392; DOI: 10.1093/nar/gky990

実験手法

X-RAY DIFFRACTION (2.8 Å)