6GH9

USP15 catalytic domain in complex with small molecule

Summary for 6GH9

• Entry DOI: 10.2210/pdb6gh9/pdb
• Related: 6GHA
• Descriptor: Ubiquitin carboxyl-terminal hydrolase 15, ZINC ION, DIMETHYL SULFOXIDE, ... (5 entities in total)
• Functional Keywords: protease, ubiquitin, ubiquitin specific protease, inhibitor, mitoxantrone, hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 84082.50

Authors

Ward, S.J.,Gratton, H.E.,Caulton, S.G.,Emsley, J.,Dreveny, I. (deposition date: 2018-05-06, release date: 2018-09-26, Last modification date: 2024-01-17)

• Primary citation: Ward, S.J.,Gratton, H.E.,Indrayudha, P.,Michavila, C.,Mukhopadhyay, R.,Maurer, S.K.,Caulton, S.G.,Emsley, J.,Dreveny, I.; The structure of the deubiquitinase USP15 reveals a misaligned catalytic triad and an open ubiquitin-binding channel.; J. Biol. Chem., 293:17362-17374, 2018; PubMed: 30228188; DOI: 10.1074/jbc.RA118.003857

Experimental method

X-RAY DIFFRACTION (2.09 Å)