6GH9

USP15 catalytic domain in complex with small molecule

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004843	molecular_function	cysteine-type deubiquitinase activity
A	0016579	biological_process	protein deubiquitination
B	0004843	molecular_function	cysteine-type deubiquitinase activity
B	0016579	biological_process	protein deubiquitination

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1001

Chain	Residue
A	CYS419
A	CYS422
A	CYS780
A	CYS783

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site_id	AC2
Number of Residues	2
Details	binding site for residue DMS A 1002

Chain	Residue
A	ASP300
A	ARG371

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site_id	AC3
Number of Residues	5
Details	binding site for residue MIX A 1003

Chain	Residue
A	HIS862
A	ASP879
A	ASN264
A	TYR855
A	GLY856

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Functional Information from PROSITE/UniProt

site_id	PS00972
Number of Residues	16
Details	USP_1 Ubiquitin specific protease (USP) domain signature 1. GLsnlGNtCFMNSaIQ

Chain	Residue	Details
A	GLY261-GLN276

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site_id	PS00973
Number of Residues	18
Details	USP_2 Ubiquitin specific protease (USP) domain signature 2. YnLiAVsnHyGgmgg..GHY

Chain	Residue	Details
A	TYR846-TYR863

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Nucleophile => ECO:0000255|PROSITE-ProRule:PRU01035, ECO:0000305|PubMed:19553310, ECO:0000305|PubMed:21947082, ECO:0000305|PubMed:22344298, ECO:0000305|PubMed:24852371, ECO:0000305|PubMed:27368102, ECO:0000305|PubMed:33093067

Chain	Residue	Details
A	ASN298
B	ASN298

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site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093

Chain	Residue	Details
A	ILE891
B	ILE891

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