6GH9

USP15 catalytic domain in complex with small molecule

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Ubiquitin carboxyl-terminal hydrolase 15	polymer	365	41747.2	2	UniProt (Q9Y4E8) Pfam (PF00443)	Homo sapiens (Human)	Deubiquitinating enzyme 15,Ubiquitin thioesterase 15,Ubiquitin-specific-processing protease 15,Unph-2,Unph4
2	C (A)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
3	D (A)	DIMETHYL SULFOXIDE	non-polymer		78.1	1	Chemie (DMS)
4	E (A)	1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE	non-polymer		444.5	1	Chemie (MIX)
5	F, G (A, B)	water	water		18.0	153	Chemie (HOH)

Sequence modifications

A, B: 255 - 439 (UniProt: Q9Y4E8)

PDB	External Database	Details
Met 254	-	initiating methionine

A, B: 757 - 922 (UniProt: Q9Y4E8)

PDB	External Database	Details
Ala 440	-	linker
Ser 753	-	linker
Thr 754	-	linker
Ser 755	-	linker
Lys 756	-	linker
Ala 920	Lys 920	conflict
Ala 921	Gly 921	conflict
Leu 923	-	expression tag
Glu 924	-	expression tag
His 925	-	expression tag
His 926	-	expression tag
His 927	-	expression tag
His 928	-	expression tag
His 929	-	expression tag
His 930	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	83494.5
Non-Polymers*	Number of molecules	3
	Total formula weight	588.0
All*	Total formula weight	84082.5

*Water molecules are not included.