6GCW

Focal Adhesion Kinase catalytic domain in complex with irreversible inhibitor

Summary for 6GCW

• Entry DOI: 10.2210/pdb6gcw/pdb
• Related: 6GCR 6GCX
• Descriptor: Focal adhesion kinase 1, 2-[[5-chloranyl-2-[[4-[[[1-[2-(propanoylamino)ethyl]-1,2,3-triazol-4-yl]methylamino]methyl]phenyl]amino]pyrimidin-4-yl]amino]-~{N}-methyl-benzamide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: focal adhesion kinase cell adhesion signalling irreversible inhibitor 2, 4-pyrimidine derivatives, cell adhesion
• Biological source: Gallus gallus (Chicken)
• Total number of polymer chains: 2
• Total formula weight: 64685.78

Authors

Yen-Pon, E.,Li, B.,Acebron-Garcia-de-Eulate, M.,Tomkiewicz-Raulet, C.,Dawson, J.,Lietha, D.,Frame, M.C.,Coumoul, X.,Garbay, C.,Etheve-Quelquejeu, M.,Chen, H. (deposition date: 2018-04-19, release date: 2019-05-01, Last modification date: 2019-10-02)

• Primary citation: Yen-Pon, E.,Li, B.,Acebron-Garcia-de-Eulate, M.,Tomkiewicz-Raulet, C.,Dawson, J.,Lietha, D.,Frame, M.C.,Coumoul, X.,Garbay, C.,Etheve-Quelquejeu, M.,Chen, H.; Structure-Based Design, Synthesis, and Characterization of the First Irreversible Inhibitor of Focal Adhesion Kinase.; Acs Chem.Biol., 13:2067-2073, 2018; PubMed: 29897729; DOI: 10.1021/acschembio.8b00250

Experimental method

X-RAY DIFFRACTION (2 Å)