Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6GBX

Crystal structure of human glutaminyl cyclase variant Y115E-Y117E in complex with SEN177

Summary for 6GBX
Entry DOI10.2210/pdb6gbx/pdb
Related4yu9 4ywy
DescriptorGlutaminyl-peptide cyclotransferase, ZINC ION, SULFATE ION, ... (6 entities in total)
Functional Keywordsinhibitor, cyclotransferase, zinc enzyme, alzheimer, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains3
Total formula weight115208.75
Authors
Pozzi, C.,Di Pisa, F.,Benvenuti, M.,Mangani, S. (deposition date: 2018-04-16, release date: 2018-09-19, Last modification date: 2024-01-17)
Primary citationPozzi, C.,Di Pisa, F.,Benvenuti, M.,Mangani, S.
The structure of the human glutaminyl cyclase-SEN177 complex indicates routes for developing new potent inhibitors as possible agents for the treatment of neurological disorders.
J. Biol. Inorg. Chem., 23:1219-1226, 2018
Cited by
PubMed: 30132075
DOI: 10.1007/s00775-018-1605-1
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.72 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon