4YWY
Crystal Structure of double mutant Y115E Y117E human Glutaminyl Cyclase in complex with inhibitor PBD-150
Summary for 4YWY
Entry DOI | 10.2210/pdb4ywy/pdb |
Descriptor | Glutaminyl-peptide cyclotransferase, ZINC ION, 1-(3,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea, ... (7 entities in total) |
Functional Keywords | alzheimer disease, cyclotransferase soluble variant, pbd-150 inhibitor, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Secreted : Q16769 |
Total number of polymer chains | 3 |
Total formula weight | 125483.44 |
Authors | Di Pisa, F.,Pozzi, C.,Benvenuti, M.,Mangani, S. (deposition date: 2015-03-21, release date: 2015-08-05, Last modification date: 2024-01-10) |
Primary citation | DiPisa, F.,Pozzi, C.,Benvenuti, M.,Andreini, M.,Marconi, G.,Mangani, S. The soluble Y115E-Y117E variant of human glutaminyl cyclase is a valid target for X-ray and NMR screening of inhibitors against Alzheimer disease. Acta Crystallogr.,Sect.F, 71:986-992, 2015 Cited by PubMed: 26249687DOI: 10.1107/S2053230X15010389 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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