6GBX
Crystal structure of human glutaminyl cyclase variant Y115E-Y117E in complex with SEN177
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Glutaminyl-peptide cyclotransferase | polymer | 329 | 37489.3 | 3 | UniProt (Q16769) Pfam (PF04389) | Homo sapiens (Human) | Glutaminyl cyclase,sQC,Glutaminyl-tRNA cyclotransferase,Glutamyl cyclase,EC |
| 2 | D, L, X (A, B, C) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 3 | E, M, Y (A, B, C) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 4 | F, N, Z (A, B, C) | 2-fluoranyl-5-[2-[4-(4-methyl-1,2,4-triazol-3-yl)piperidin-1-yl]pyridin-3-yl]pyridine | non-polymer | 338.4 | 3 | Chemie (S77) | |||
| 5 | AA, BA, CA, DA, EA... (C, A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 20 | Chemie (EDO) | |||
| 6 | GA, HA, IA (A, B, C) | water | water | 18.0 | 697 | Chemie (HOH) |
Sequence modifications
A, B, C: 33 - 361 (UniProt: Q16769)
| PDB | External Database | Details |
|---|---|---|
| Glu 115 | Tyr 115 | engineered mutation |
| Glu 117 | Tyr 117 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 112467.8 | |
| Non-Polymers* | Number of molecules | 29 |
| Total formula weight | 2740.9 | |
| All* | Total formula weight | 115208.8 |
