6G5J

Secreted phospholipase A2 type X in complex with ligand

Summary for 6G5J

• Entry DOI: 10.2210/pdb6g5j/pdb
• Descriptor: Group 10 secretory phospholipase A2, CALCIUM ION, (3~{R})-3-[3-[2-aminocarbonyl-6-(trifluoromethyloxy)indol-1-yl]phenyl]butanoic acid, ... (6 entities in total)
• Functional Keywords: secretory phospholipase a2 type x spla2x spla2-x phospholipase enzyme inhibitor complex, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 37826.02

Authors

Sandmark, J.,Oster, L. (deposition date: 2018-03-29, release date: 2018-09-05)

• Primary citation: Giordanetto, F.,Knerr, L.,Nordberg, P.,Pettersen, D.,Selmi, N.,Beisel, H.G.,de la Motte, H.,Mansson, A.,Dahlstrom, M.,Broddefalk, J.,Saarinen, G.,Klingegard, F.,Hurt-Camejo, E.,Rosengren, B.,Wikstrom, J.,Wagberg, M.,Brengdahl, J.,Rohman, M.,Sandmark, J.,Akerud, T.,Roth, R.G.,Jansen, F.,Ahlqvist, M.; Design of Selective sPLA2-X Inhibitor (-)-2-{2-[Carbamoyl-6-(trifluoromethoxy)-1H-indol-1-yl]pyridine-2-yl}propanoic Acid.; ACS Med Chem Lett, 9:600-605, 2018; PubMed: 30034586; DOI: 10.1021/acsmedchemlett.7b00507

Experimental method

X-RAY DIFFRACTION (1.85 Å)