6G3C

Crystal Structure of JAK2-V617F pseudokinase domain in complex with Compound 2

Summary for 6G3C

Entry DOI	10.2210/pdb6g3c/pdb
Descriptor	Tyrosine-protein kinase, 2-[[3,5-bis(fluoranyl)-4-oxidanyl-phenyl]amino]-5,7,7-trimethyl-8-(3-methylbutyl)pteridin-6-one, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	janus protein kinase, pseudokinase, phosphotransferase, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	63895.31
Authors	Dekker, C.,Hinniger, A. (deposition date: 2018-03-24, release date: 2019-03-27, Last modification date: 2024-01-17)
Primary citation	McNally, R.,Li, Q.,Li, K.,Dekker, C.,Vangrevelinghe, E.,Jones, M.,Chene, P.,Machauer, R.,Radimerski, T.,Eck, M.J. Discovery and Structural Characterization of ATP-Site Ligands for the Wild-Type and V617F Mutant JAK2 Pseudokinase Domain. Acs Chem.Biol., 14:587-593, 2019 Cited by PubMed: 30763067 DOI: 10.1021/acschembio.8b00722 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation