6G3C
Crystal Structure of JAK2-V617F pseudokinase domain in complex with Compound 2
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Tyrosine-protein kinase | polymer | 272 | 31169.8 | 2 | UniProt (Q506Q0) Pfam (PF07714) UniProt (by SIFTS) (O60674) In PDB | Homo sapiens (Human) | |
2 | A, B | 2-[[3,5-bis(fluoranyl)-4-oxidanyl-phenyl]amino]-5,7,7-trimethyl-8-(3-methylbutyl)pteridin-6-one | non-polymer | 405.4 | 2 | Chemie (EKT) | |||
3 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 12 | Chemie (EDO) | |||
4 | water | water | 18.0 | 462 | Chemie (HOH) |
Sequence modifications
A, B: 537 - 808 (UniProt: Q506Q0)
PDB | External Database | Details |
---|---|---|
Ala 659 | Trp 659 | engineered mutation |
Ala 777 | Trp 777 | engineered mutation |
His 794 | Phe 794 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 62339.6 | |
Non-Polymers* | Number of molecules | 14 |
Total formula weight | 1555.7 | |
All* | Total formula weight | 63895.3 |