6FZ3

Human N-myristoyltransferase (NMT1) with Myristoyl-CoA and inhibitor bound

Summary for 6FZ3

Entry DOI	10.2210/pdb6fz3/pdb
Related	3IU1 3IU2 3IWE 4C2Z 6FZ2
Descriptor	Glycylpeptide N-tetradecanoyltransferase 1, 2,6-bis(chloranyl)-4-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]-~{N}-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamide, TETRADECANOYL-COA, ... (6 entities in total)
Functional Keywords	protein-ligand complex, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	97039.19
Authors	Kersten, F.C.,Brenk, R. (deposition date: 2018-03-13, release date: 2019-03-27, Last modification date: 2024-01-17)
Primary citation	Kersten, C.,Fleischer, E.,Kehrein, J.,Borek, C.,Jaenicke, E.,Sotriffer, C.,Brenk, R. How To Design Selective Ligands for Highly Conserved Binding Sites: A Case Study UsingN-Myristoyltransferases as a Model System. J.Med.Chem., 63:2095-2113, 2020 Cited by PubMed: 31423787 DOI: 10.1021/acs.jmedchem.9b00586 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation