6FZ3

Human N-myristoyltransferase (NMT1) with Myristoyl-CoA and inhibitor bound

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Glycylpeptide N-tetradecanoyltransferase 1	polymer	403	46915.9	2	UniProt (P30419) Pfam (PF01233) Pfam (PF02799) In PDB	Homo sapiens (Human)	Myristoyl-CoA:protein N-myristoyltransferase 1,Type I N-myristoyltransferase,Peptide N-myristoyltransferase 1
2	A, B	2,6-bis(chloranyl)-4-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]-~{N}-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamide	non-polymer		509.5	2	Chemie (EBK)
3	A, B	TETRADECANOYL-COA	non-polymer		977.9	2	Chemie (MYA)
4	A, B	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
5	A, B	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
6		water	water		18.0	181	Chemie (HOH)

Sequence modifications

A, B: 115 - 496 (UniProt: P30419)

PDB	External Database	Details
Met 94	-	initiating methionine
Gly 95	-	expression tag
Ser 96	-	expression tag
Ser 97	-	expression tag
His 98	-	expression tag
His 99	-	expression tag
His 100	-	expression tag
His 101	-	expression tag
His 102	-	expression tag
His 103	-	expression tag
Ser 104	-	expression tag
Ser 105	-	expression tag
Gly 106	-	expression tag
Arg 107	-	expression tag
Glu 108	-	expression tag
Asn 109	-	expression tag
Leu 110	-	expression tag
Tyr 111	-	expression tag
Phe 112	-	expression tag
Gln 113	-	expression tag
Gly 114	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	93831.7
Non-Polymers*	Number of molecules	8
	Total formula weight	3207.5
All*	Total formula weight	97039.2

*Water molecules are not included.