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3IWE

Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD85646

Summary for 3IWE
Entry DOI10.2210/pdb3iwe/pdb
Related3IU1 3IU2
DescriptorGlycylpeptide N-tetradecanoyltransferase 1, TETRADECANOYL-COA, 2,6-dichloro-4-(2-piperazin-1-ylpyridin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide, ... (4 entities in total)
Functional Keywordstransferase, n-myristoyltransferase, nmt, acyltransferase, phosphoprotein, structural genomics, structural genomics consortium, sgc
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: P30419
Total number of polymer chains2
Total formula weight92029.29
Authors
Primary citationQiu, W.,Hutchinson, A.,Wernimont, A.,Lin, Y.-H.,Kania, A.,Ravichandran, M.,Kozieradzki, I.,Cossar, D.,Schapira, M.,Arrowsmith, C.H.,Bountra, C.,Weigelt, J.,Edwards, A.M.,Wyatt, P.G.,Ferguson, M.A.J.,Frearson, J.A.,Brand, S.Y.,Robinson, D.A.,Bochkarev, A.,Hui, R.
Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD85646
To be Published,
Experimental method
X-RAY DIFFRACTION (1.79 Å)
Structure validation

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PDB entries from 2024-03-13

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