3IWE
Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD85646
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 36 |
| Details | BINDING SITE FOR RESIDUE MYA A 1001 |
| Chain | Residue |
| A | HOH75 |
| A | PHE247 |
| A | LEU248 |
| A | CYS249 |
| A | VAL250 |
| A | ARG255 |
| A | SER256 |
| A | LYS257 |
| A | ARG258 |
| A | VAL259 |
| A | ALA260 |
| A | HOH83 |
| A | PRO261 |
| A | THR268 |
| A | VAL271 |
| A | PHE277 |
| A | TYR281 |
| A | THR282 |
| A | LEU287 |
| A | TYR479 |
| A | HOH526 |
| A | HOH529 |
| A | TYR117 |
| A | HOH560 |
| A | HOH617 |
| A | HOH618 |
| A | HOH632 |
| A | HOH741 |
| A | HOH752 |
| A | 6461002 |
| A | GLN118 |
| A | PHE119 |
| A | TRP120 |
| A | ASN179 |
| A | TYR180 |
| A | VAL181 |
| site_id | AC2 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE 646 A 1002 |
| Chain | Residue |
| A | HOH2 |
| A | VAL181 |
| A | ASP183 |
| A | PHE188 |
| A | PHE190 |
| A | ASN246 |
| A | GLY284 |
| A | TYR296 |
| A | HIS298 |
| A | PHE311 |
| A | SER405 |
| A | TYR420 |
| A | GLY472 |
| A | GLN496 |
| A | HOH547 |
| A | HOH753 |
| A | HOH760 |
| A | HOH970 |
| A | MYA1001 |
| site_id | AC3 |
| Number of Residues | 37 |
| Details | BINDING SITE FOR RESIDUE MYA B 2001 |
| Chain | Residue |
| B | HOH103 |
| B | TYR117 |
| B | GLN118 |
| B | PHE119 |
| B | TRP120 |
| B | ASN179 |
| B | TYR180 |
| B | VAL181 |
| B | ASN246 |
| B | PHE247 |
| B | LEU248 |
| B | CYS249 |
| B | VAL250 |
| B | ARG255 |
| B | SER256 |
| B | LYS257 |
| B | ARG258 |
| B | VAL259 |
| B | ALA260 |
| B | PRO261 |
| B | THR268 |
| B | PHE277 |
| B | TYR281 |
| B | THR282 |
| B | LEU287 |
| B | TYR479 |
| B | HOH548 |
| B | HOH669 |
| B | HOH680 |
| B | HOH725 |
| B | HOH766 |
| B | HOH788 |
| B | HOH789 |
| B | HOH800 |
| B | HOH989 |
| B | HOH1010 |
| B | 6462002 |
| site_id | AC4 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE 646 B 2002 |
| Chain | Residue |
| B | THR282 |
| B | GLY284 |
| B | TYR296 |
| B | HIS298 |
| B | PHE311 |
| B | SER405 |
| B | TYR420 |
| B | ASP471 |
| B | GLN496 |
| B | HOH529 |
| B | HOH731 |
| B | HOH744 |
| B | HOH1068 |
| B | MYA2001 |
| B | HOH1 |
| B | TYR180 |
| B | VAL181 |
| B | ASP183 |
| B | PHE188 |
| B | PHE190 |
| B | ASN246 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25255805","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32111831","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90055.","authoringGroup":["Structural genomics consortium (SGC)"]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25255805","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32103017","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32111831","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90055.","authoringGroup":["Structural genomics consortium (SGC)"]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"32103017","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25255805","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90055.","authoringGroup":["Structural genomics consortium (SGC)"]}}]} |
| Chain | Residue | Details |
