6FYM
Human PARP14 (ARTD8), catalytic fragment in complex with inhibitor ITK1
Summary for 6FYM
| Entry DOI | 10.2210/pdb6fym/pdb |
| Descriptor | Poly [ADP-ribose] polymerase 14, 7,8-dimethyl-2-(pyrimidin-2-ylsulfanylmethyl)-3~{H}-quinazolin-4-one, NITRATE ION, ... (4 entities in total) |
| Functional Keywords | adp-ribosylation, inhibitor complex, transferase domain, transferase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 4 |
| Total formula weight | 89791.82 |
| Authors | Karlberg, T.,Thorsell, A.G.,Kirby, I.T.,Sreenivasan, R.,Cohen, M.S.,Schuler, H. (deposition date: 2018-03-12, release date: 2019-02-20, Last modification date: 2024-01-17) |
| Primary citation | Kirby, I.T.,Kojic, A.,Arnold, M.R.,Thorsell, A.G.,Karlberg, T.,Vermehren-Schmaedick, A.,Sreenivasan, R.,Schultz, C.,Schuler, H.,Cohen, M.S. A Potent and Selective PARP11 Inhibitor Suggests Coupling between Cellular Localization and Catalytic Activity. Cell Chem Biol, 25:1547-1553.e12, 2018 Cited by PubMed: 30344052DOI: 10.1016/j.chembiol.2018.09.011 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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