6FEB

Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-1086

6FEB の概要

• エントリーDOI: 10.2210/pdb6feb/pdb
• 関連するPDBエントリー: 6FDI 6FDS 6FDW 6FDX 6FE3 6FE7
• 分子名称: cAMP-specific 3',5'-cyclic phosphodiesterase 4D, 1,2-ETHANEDIOL, (4aS,8aR)-2-[1-(2-aminoquinazolin-4-yl)piperidin-4-yl]-4-(3,4-dimethoxyphenyl)-1,2,4a,5,8,8a-hexahydrophthalazin-1-one, ... (7 entities in total)
• 機能のキーワード: phosphodiesterase, hydrolase, camp hydrolysis, alternative splicing
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 86989.62

構造登録者

Singh, A.K.,Brown, D.G. (登録日: 2017-12-31, 公開日: 2019-04-10, 最終更新日: 2024-01-17)

• 主引用文献: Salado, I.G.,Moreno, C.,Sakaine, G.,Singh, A.K.,Blaazer, A.R.,Siderius, M.,Matheeussen, A.,Gul, S.,Maes, L.,Leurs, R.,Brown, D.G.,Augustyns, K.; hPDE4D2 structure with inhibitor NPD-1086; To be published,

実験手法

X-RAY DIFFRACTION (1.93 Å)