6FD6

Crystal Structure of Human APRT-Tyr105Phe variant in complex with Adenine, PRPP and Mg2+, 30 days post crystallization (with AMP and PPi products fully generated)

Summary for 6FD6

Entry DOI	10.2210/pdb6fd6/pdb
Related	6FCH 6FCI 6FCL 6FD4 6FD5
Descriptor	Adenine phosphoribosyltransferase, ADENOSINE MONOPHOSPHATE, PYROPHOSPHATE, ... (5 entities in total)
Functional Keywords	rossman fold, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	39897.60
Authors	Nioche, P.,Huyet, J.,Ozeir, M. (deposition date: 2017-12-21, release date: 2018-08-15, Last modification date: 2024-01-17)
Primary citation	Huyet, J.,Ozeir, M.,Burgevin, M.C.,Pinson, B.,Chesney, F.,Remy, J.M.,Siddiqi, A.R.,Lupoli, R.,Pinon, G.,Saint-Marc, C.,Gibert, J.F.,Morales, R.,Ceballos-Picot, I.,Barouki, R.,Daignan-Fornier, B.,Olivier-Bandini, A.,Auge, F.,Nioche, P. Structural Insights into the Forward and Reverse Enzymatic Reactions in Human Adenine Phosphoribosyltransferase. Cell Chem Biol, 25:666-676.e4, 2018 Cited by PubMed: 29576532 DOI: 10.1016/j.chembiol.2018.02.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation