6EU5

Leishmania major N-myristoyltransferase with bound myristoyl-CoA and inhibitor

6EU5 の概要

• エントリーDOI: 10.2210/pdb6eu5/pdb
• 関連するPDBエントリー: 2WSA
• 分子名称: Glycylpeptide N-tetradecanoyltransferase, TETRADECANOYL-COA, 4-[3-[(8~{a}~{R})-3,4,6,7,8,8~{a}-hexahydro-1~{H}-pyrrolo[1,2-a]pyrazin-2-yl]propyl]-2,6-bis(chloranyl)-~{N}-methyl-~{N}-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamide, ... (4 entities in total)
• 機能のキーワード: n-myristoyltransferase, selective inhibitor, parasite, transferase
• 由来する生物種: Leishmania major
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 52005.65

構造登録者

Brenk, R.,Kehrein, J.,Kersten, C. (登録日: 2017-10-27, 公開日: 2019-02-06, 最終更新日: 2024-01-17)

• 主引用文献: Kersten, C.,Fleischer, E.,Kehrein, J.,Borek, C.,Jaenicke, E.,Sotriffer, C.,Brenk, R.; How To Design Selective Ligands for Highly Conserved Binding Sites: A Case Study UsingN-Myristoyltransferases as a Model System.; J.Med.Chem., 2019; PubMed: 31423787; DOI: 10.1021/acs.jmedchem.9b00586

実験手法

X-RAY DIFFRACTION (1.49608302465 Å)