6EU5

Leishmania major N-myristoyltransferase with bound myristoyl-CoA and inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Glycylpeptide N-tetradecanoyltransferase	polymer	438	50513.3	1	UniProt (Q4Q5S8) Pfam (PF01233) Pfam (PF02799)	Leishmania major
2	B (A)	TETRADECANOYL-COA	non-polymer		977.9	1	Chemie (MYA)
3	C (A)	4-[3-[(8~{a}~{R})-3,4,6,7,8,8~{a}-hexahydro-1~{H}-pyrrolo[1,2-a]pyrazin-2-yl]propyl]-2,6-bis(chloranyl)-~{N}-methyl-~{N}-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamide	non-polymer		514.5	1	Chemie (BXN)
4	D (A)	water	water		18.0	227	Chemie (HOH)

Sequence modifications

A: -5 - 411 (UniProt: Q4Q5S8)

PDB	External Database	Details
Met -26	-	initiating methionine
Gly -25	-	expression tag
Ser -24	-	expression tag
Ser -23	-	expression tag
His -22	-	expression tag
His -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
Ser -16	-	expression tag
Ser -15	-	expression tag
Gly -14	-	expression tag
Arg -13	-	expression tag
Glu -12	-	expression tag
Asn -11	-	expression tag
Leu -10	-	expression tag
Tyr -9	-	expression tag
Phe -8	-	expression tag
Gln -7	-	expression tag
Gly -6	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	50513.3
Non-Polymers*	Number of molecules	2
	Total formula weight	1492.4
All*	Total formula weight	52005.7

*Water molecules are not included.