6EPA
Structure of dNCS-1 bound to the NCS-1/Ric8a protein/protein interaction regulator IGS-1.76
Summary for 6EPA
Entry DOI | 10.2210/pdb6epa/pdb |
Descriptor | FI18190p1, CALCIUM ION, ~{N}-(1,3-benzothiazol-2-yl)-3,3-diphenyl-propanamide, ... (6 entities in total) |
Functional Keywords | calcium sensor, synapse regulation, signaling protein |
Biological source | Drosophila melanogaster (Fruit fly) |
Total number of polymer chains | 1 |
Total formula weight | 22544.27 |
Authors | Sanchez-Barrena, M.J.,Daniel, M.,Infantes, L. (deposition date: 2017-10-11, release date: 2018-08-29, Last modification date: 2024-01-17) |
Primary citation | Roca, C.,Martinez-Gonzalez, L.,Daniel-Mozo, M.,Sastre, J.,Infantes, L.,Mansilla, A.,Chaves-Sanjuan, A.,Gonzalez-Rubio, J.M.,Gil, C.,Canada, F.J.,Martinez, A.,Sanchez-Barrena, M.J.,Campillo, N.E. Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Synapse Function Regulators. J. Med. Chem., 61:5910-5921, 2018 Cited by PubMed: 29966094DOI: 10.1021/acs.jmedchem.8b00088 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.82 Å) |
Structure validation
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