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6EPA

Structure of dNCS-1 bound to the NCS-1/Ric8a protein/protein interaction regulator IGS-1.76

Summary for 6EPA
Entry DOI10.2210/pdb6epa/pdb
DescriptorFI18190p1, CALCIUM ION, ~{N}-(1,3-benzothiazol-2-yl)-3,3-diphenyl-propanamide, ... (6 entities in total)
Functional Keywordscalcium sensor, synapse regulation, signaling protein
Biological sourceDrosophila melanogaster (Fruit fly)
Total number of polymer chains1
Total formula weight22544.27
Authors
Sanchez-Barrena, M.J.,Daniel, M.,Infantes, L. (deposition date: 2017-10-11, release date: 2018-08-29, Last modification date: 2024-01-17)
Primary citationRoca, C.,Martinez-Gonzalez, L.,Daniel-Mozo, M.,Sastre, J.,Infantes, L.,Mansilla, A.,Chaves-Sanjuan, A.,Gonzalez-Rubio, J.M.,Gil, C.,Canada, F.J.,Martinez, A.,Sanchez-Barrena, M.J.,Campillo, N.E.
Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Synapse Function Regulators.
J. Med. Chem., 61:5910-5921, 2018
Cited by
PubMed: 29966094
DOI: 10.1021/acs.jmedchem.8b00088
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.82 Å)
Structure validation

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