6EPA
Structure of dNCS-1 bound to the NCS-1/Ric8a protein/protein interaction regulator IGS-1.76
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0007268 | biological_process | chemical synaptic transmission |
| A | 0007269 | biological_process | neurotransmitter secretion |
| A | 0007528 | biological_process | neuromuscular junction development |
| A | 0008021 | cellular_component | synaptic vesicle |
| A | 0008048 | molecular_function | calcium sensitive guanylate cyclase activator activity |
| A | 0009966 | biological_process | regulation of signal transduction |
| A | 0016192 | biological_process | vesicle-mediated transport |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0046928 | biological_process | regulation of neurotransmitter secretion |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 201 |
| Chain | Residue |
| A | ASP73 |
| A | ASN75 |
| A | ASP77 |
| A | ALA79 |
| A | GLU84 |
| A | HOH331 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 202 |
| Chain | Residue |
| A | ARG162 |
| A | GLU167 |
| A | HOH304 |
| A | ASP156 |
| A | ASN158 |
| A | ASP160 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 203 |
| Chain | Residue |
| A | ASP109 |
| A | ASP111 |
| A | ASP113 |
| A | TYR115 |
| A | GLU120 |
| A | HOH351 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue BNQ A 204 |
| Chain | Residue |
| A | TRP30 |
| A | ILE51 |
| A | TYR52 |
| A | THR92 |
| A | TRP103 |
| A | LEU182 |
| A | HOH349 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 206 |
| Chain | Residue |
| A | ARG70 |
| A | ASP73 |
| A | ASN76 |
| A | HOH311 |
| A | HOH405 |
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DENNDGAIEfeEF |
| Chain | Residue | Details |
| A | ASP73-PHE85 | |
| A | ASP109-MET121 | |
| A | ASP156-PHE168 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 25 |
| Details | Domain: {"description":"EF-hand 1","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 35 |
| Details | Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 35 |
| Details | Domain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 35 |
| Details | Domain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 15 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25074811","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28119500","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29966094","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BY4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BY5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AAN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FYX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5G08","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6EPA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
