6EP8
InhA Y158F mutant in complex with NADH from Mycobacterium tuberculosis
Summary for 6EP8
Entry DOI | 10.2210/pdb6ep8/pdb |
Descriptor | Enoyl-[acyl-carrier-protein] reductase [NADH], SODIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (6 entities in total) |
Functional Keywords | mycolic acid biosynthetic process, oxidoreductase, therapeutic target, isoniazid, mutation, catalytic mechanism, enoyl thioester reductases, tuberculosis |
Biological source | Mycobacterium tuberculosis H37Rv |
Total number of polymer chains | 1 |
Total formula weight | 30247.18 |
Authors | Wagner, T.,Voegeli, B.,Rosenthal, R.G.,Stoffel, G.,Shima, S.,Kiefer, P.,Cortina, N.,Erb, T.J. (deposition date: 2017-10-11, release date: 2018-09-19, Last modification date: 2024-01-17) |
Primary citation | Vogeli, B.,Rosenthal, R.G.,Stoffel, G.M.M.,Wagner, T.,Kiefer, P.,Cortina, N.S.,Shima, S.,Erb, T.J. InhA, the enoyl-thioester reductase fromMycobacterium tuberculosisforms a covalent adduct during catalysis. J. Biol. Chem., 293:17200-17207, 2018 Cited by PubMed: 30217823DOI: 10.1074/jbc.RA118.005405 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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