6EO8
Crystal structure of thrombin in complex with a novel glucose-conjugated potent inhibitor
Replaces: 4N3LSummary for 6EO8
Entry DOI | 10.2210/pdb6eo8/pdb |
Descriptor | Prothrombin, Hirudin variant-2, DIMETHYL SULFOXIDE, ... (6 entities in total) |
Functional Keywords | hydrolase-hydrolase inhibitor complex, blood clotting |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 36576.31 |
Authors | Belviso, B.D.,Caliandro, R.,Aresta, B.M.,De Candia, M.,Altomare, C.D. (deposition date: 2017-10-09, release date: 2017-12-13, Last modification date: 2019-10-16) |
Primary citation | Belviso, B.D.,Caliandro, R.,de Candia, M.,Zaetta, G.,Lopopolo, G.,Incampo, F.,Colucci, M.,Altomare, C.D. How a beta-D-glucoside side chain enhances binding affinity to thrombin of inhibitors bearing 2-chlorothiophene as P1 moiety: crystallography, fragment deconstruction study, and evaluation of antithrombotic properties. J. Med. Chem., 57:8563-8575, 2014 Cited by PubMed: 25268757DOI: 10.1021/jm5010754 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.94 Å) |
Structure validation
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