6EO8

Crystal structure of thrombin in complex with a novel glucose-conjugated potent inhibitor

Replaces:  4N3L

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	L	Prothrombin	polymer	36	4096.5	1	UniProt (P00734) Pfam (PF09396) In PDB	Homo sapiens (Human)	Coagulation factor II
2	H	Prothrombin	polymer	259	29780.2	1	UniProt (P00734) Pfam (PF00089) In PDB	Homo sapiens (Human)	Coagulation factor II
3	I	Hirudin variant-2	polymer	12	1534.6	1	UniProt (P09945) In PDB	Hirudo medicinalis (Medicinal leech)
4	H	DIMETHYL SULFOXIDE	non-polymer		78.1	6	Chemie (DMS)
5	H	N-(2-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methoxy}-6-[3-(beta-D-glucopyranosyloxy)propoxy]phenyl)-1-(propan-2-yl)piperidine-4-carboxamide	non-polymer		696.2	1	Chemie (2FN)
6		water	water		18.0	80	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	35411.3
Non-Polymers*	Number of molecules	7
	Total formula weight	1165.0
All*	Total formula weight	36576.3

*Water molecules are not included.