6ENM

Crystal structure of MMP12 in complex with hydroxamate inhibitor LP168.

Summary for 6ENM

• Entry DOI: 10.2210/pdb6enm/pdb
• Related: 6EKN 6ELA
• Descriptor: Macrophage metalloelastase, 2-[2-[4-(4-methoxyphenyl)phenyl]sulfonylphenyl]-~{N}-oxidanyl-ethanamide, ZINC ION, ... (5 entities in total)
• Functional Keywords: metzincin, carboxylate inhibitor alternative zinc-binding groups, hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 36528.33

Authors

Vera, L.,Nuti, E.,Rossello, A.,Stura, E.A. (deposition date: 2017-10-05, release date: 2018-05-16, Last modification date: 2024-01-17)

• Primary citation: Nuti, E.,Cuffaro, D.,Bernardini, E.,Camodeca, C.,Panelli, L.,Chaves, S.,Ciccone, L.,Tepshi, L.,Vera, L.,Orlandini, E.,Nencetti, S.,Stura, E.A.,Santos, M.A.,Dive, V.,Rossello, A.; Development of Thioaryl-Based Matrix Metalloproteinase-12 Inhibitors with Alternative Zinc-Binding Groups: Synthesis, Potentiometric, NMR, and Crystallographic Studies.; J. Med. Chem., 61:4421-4435, 2018; PubMed: 29727184; DOI: 10.1021/acs.jmedchem.8b00096

Experimental method

X-RAY DIFFRACTION (1.59 Å)