6EIX

Crystal structure of the kinase domain of the Q207E mutant of ACVR1 (ALK2) in complex with a 2-aminopyridine inhibitor K02288

Summary for 6EIX

• Entry DOI: 10.2210/pdb6eix/pdb
• Descriptor: Activin receptor type-1, 3-[6-amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: kinase, alk2, receptor, bmp, structural genomics, structural genomics consortium, sgc, signaling protein
• Biological source: Homo sapiens (Human)
• Cellular location: Membrane; Single-pass type I membrane protein: Q04771
• Total number of polymer chains: 1
• Total formula weight: 39431.00

Authors

Williams, E.P.,Canning, P.,Sanvitale, C.E.,Krojer, T.,Allerston, C.K.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.N. (deposition date: 2017-09-19, release date: 2017-09-27, Last modification date: 2024-01-17)

• Primary citation: Williams, E.P.,Canning, P.,Sanvitale, C.E.,Bullock, A.N.; Crystal structure of the kinase domain of the Q207E mutant of ACVR1 (ALK2) in complex with K02288; To be published,

Experimental method

X-RAY DIFFRACTION (2.3 Å)