6EIX
Crystal structure of the kinase domain of the Q207E mutant of ACVR1 (ALK2) in complex with a 2-aminopyridine inhibitor K02288
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Activin receptor type-1 | polymer | 340 | 38520.0 | 1 | UniProt (Q04771) Pfam (PF08515) Pfam (PF00069) | Homo sapiens (Human) | Activin receptor type I,ACTR-I,Activin receptor-like kinase 2,ALK-2,Serine/threonine-protein kinase receptor R1,SKR1,TGF-B superfamily receptor type I,TSR-I |
| 2 | B (A) | 3-[6-amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol | non-polymer | 352.4 | 1 | Chemie (A3F) | |||
| 3 | C, D, E, F, G... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 9 | Chemie (EDO) | |||
| 4 | L (A) | water | water | 18.0 | 64 | Chemie (HOH) |
Sequence modifications
A: 172 - 509 (UniProt: Q04771)
| PDB | External Database | Details |
|---|---|---|
| Ser 170 | - | expression tag |
| Met 171 | - | expression tag |
| Glu 207 | Gln 207 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 38520.0 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 911.0 | |
| All* | Total formula weight | 39431.0 |
