6EGS
Crystal structure of the GalNAc-T2 F104S mutant in complex with UDP-GalNAc
Summary for 6EGS
Entry DOI | 10.2210/pdb6egs/pdb |
Descriptor | Polypeptide N-acetylgalactosaminyltransferase 2, MANGANESE (II) ION, URIDINE-DIPHOSPHATE-N-ACETYLGALACTOSAMINE, ... (4 entities in total) |
Functional Keywords | f104s mutant, galnac-t2, hdl, glycosyltransferase, flexible loop, inactive/active states, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 116064.78 |
Authors | de las Rivas, M.,Coelho, H.,Diniz, A.,Lira-Navarrete, E.,Jimenez-Barbero, J.,Schjoldager, K.T.,Bennett, E.P.,Vakhrushev, S.Y.,Clausen, H.,Corzana, F.,Marcelo, F.,Hurtado-Guerrero, R. (deposition date: 2017-09-12, release date: 2018-04-11, Last modification date: 2024-01-17) |
Primary citation | de Las Rivas, M.,Coelho, H.,Diniz, A.,Lira-Navarrete, E.,Companon, I.,Jimenez-Barbero, J.,Schjoldager, K.T.,Bennett, E.P.,Vakhrushev, S.Y.,Clausen, H.,Corzana, F.,Marcelo, F.,Hurtado-Guerrero, R. Structural Analysis of a GalNAc-T2 Mutant Reveals an Induced-Fit Catalytic Mechanism for GalNAc-Ts. Chemistry, 24:8382-8392, 2018 Cited by PubMed: 29601100DOI: 10.1002/chem.201800701 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
Download full validation report