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6EGS

Crystal structure of the GalNAc-T2 F104S mutant in complex with UDP-GalNAc

Summary for 6EGS
Entry DOI10.2210/pdb6egs/pdb
DescriptorPolypeptide N-acetylgalactosaminyltransferase 2, MANGANESE (II) ION, URIDINE-DIPHOSPHATE-N-ACETYLGALACTOSAMINE, ... (4 entities in total)
Functional Keywordsf104s mutant, galnac-t2, hdl, glycosyltransferase, flexible loop, inactive/active states, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight116064.78
Authors
Primary citationde Las Rivas, M.,Coelho, H.,Diniz, A.,Lira-Navarrete, E.,Companon, I.,Jimenez-Barbero, J.,Schjoldager, K.T.,Bennett, E.P.,Vakhrushev, S.Y.,Clausen, H.,Corzana, F.,Marcelo, F.,Hurtado-Guerrero, R.
Structural Analysis of a GalNAc-T2 Mutant Reveals an Induced-Fit Catalytic Mechanism for GalNAc-Ts.
Chemistry, 24:8382-8392, 2018
Cited by
PubMed: 29601100
DOI: 10.1002/chem.201800701
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

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