6EGS
Crystal structure of the GalNAc-T2 F104S mutant in complex with UDP-GalNAc
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue MN A 601 |
| Chain | Residue |
| A | ASP224 |
| A | HIS226 |
| A | HIS359 |
| A | UD2602 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | binding site for residue UD2 A 602 |
| Chain | Residue |
| A | HIS226 |
| A | GLY308 |
| A | GLY309 |
| A | LEU310 |
| A | VAL330 |
| A | GLY332 |
| A | GLU334 |
| A | ASN335 |
| A | HIS359 |
| A | HIS365 |
| A | MN601 |
| A | THR143 |
| A | ASP176 |
| A | ARG201 |
| A | LEU204 |
| A | ASP224 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue MN B 601 |
| Chain | Residue |
| B | ASP224 |
| B | HIS226 |
| B | HIS359 |
| B | UD2602 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | binding site for residue UD2 B 602 |
| Chain | Residue |
| B | THR143 |
| B | PHE144 |
| B | HIS145 |
| B | ASP176 |
| B | ARG201 |
| B | LEU204 |
| B | ASP224 |
| B | SER225 |
| B | HIS226 |
| B | GLY308 |
| B | GLY309 |
| B | VAL330 |
| B | TRP331 |
| B | GLY332 |
| B | GLU334 |
| B | HIS359 |
| B | MN601 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16434399, ECO:0000269|PubMed:24954443, ECO:0000269|PubMed:25939779, ECO:0007744|PDB:2FFU, ECO:0007744|PDB:2FFV, ECO:0007744|PDB:4D0T, ECO:0007744|PDB:4D11, ECO:0007744|PDB:5AJP, ECO:0007744|PDB:5FV9 |
| Chain | Residue | Details |
| A | HIS365 | |
| B | THR143 | |
| B | ASP176 | |
| B | ARG201 | |
| B | SER225 | |
| B | TRP331 | |
| B | ARG362 | |
| B | HIS365 | |
| A | THR143 | |
| A | ASP176 | |
| A | ARG201 | |
| A | SER225 | |
| A | TRP331 | |
| A | ARG362 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16434399, ECO:0000269|PubMed:24954443, ECO:0000269|PubMed:25939779, ECO:0007744|PDB:2FFU, ECO:0007744|PDB:2FFV, ECO:0007744|PDB:4D0T, ECO:0007744|PDB:4D0Z, ECO:0007744|PDB:4D11, ECO:0007744|PDB:5AJP, ECO:0007744|PDB:5FV9 |
| Chain | Residue | Details |
| A | ASP224 | |
| A | HIS226 | |
| A | HIS359 | |
| B | ASP224 | |
| B | HIS226 | |
| B | HIS359 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16434399, ECO:0000269|PubMed:24954443, ECO:0000269|PubMed:25939779, ECO:0007744|PDB:2FFU, ECO:0007744|PDB:2FFV, ECO:0007744|PDB:4D0T, ECO:0007744|PDB:4D0Z, ECO:0007744|PDB:4D11, ECO:0007744|PDB:5AJN, ECO:0007744|PDB:5AJO, ECO:0007744|PDB:5AJP, ECO:0007744|PDB:5FV9, ECO:0007744|PDB:5NDF, ECO:0007744|PDB:6EGS |
| Chain | Residue | Details |
| A | TYR367 | |
| B | TYR367 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Not glycosylated |
| Chain | Residue | Details |
| A | ASN516 | |
| B | ASN516 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER536 | |
| B | SER536 |
