6EGS

Crystal structure of the GalNAc-T2 F104S mutant in complex with UDP-GalNAc

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue MN A 601

Chain	Residue
A	ASP224
A	HIS226
A	HIS359
A	UD2602

---

site_id	AC2
Number of Residues	16
Details	binding site for residue UD2 A 602

Chain	Residue
A	HIS226
A	GLY308
A	GLY309
A	LEU310
A	VAL330
A	GLY332
A	GLU334
A	ASN335
A	HIS359
A	HIS365
A	MN601
A	THR143
A	ASP176
A	ARG201
A	LEU204
A	ASP224

---

site_id	AC3
Number of Residues	4
Details	binding site for residue MN B 601

Chain	Residue
B	ASP224
B	HIS226
B	HIS359
B	UD2602

---

site_id	AC4
Number of Residues	17
Details	binding site for residue UD2 B 602

Chain	Residue
B	THR143
B	PHE144
B	HIS145
B	ASP176
B	ARG201
B	LEU204
B	ASP224
B	SER225
B	HIS226
B	GLY308
B	GLY309
B	VAL330
B	TRP331
B	GLY332
B	GLU334
B	HIS359
B	MN601

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	246
Details	Domain: {"description":"Ricin B-type lectin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00174","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	210
Details	Region: {"description":"Catalytic subdomain A"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	124
Details	Region: {"description":"Catalytic subdomain B"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	13
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16434399","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24954443","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25939779","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2FFU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FFV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4D0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4D11","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AJP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FV9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16434399","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24954443","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25939779","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2FFU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FFV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4D0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4D0Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4D11","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AJP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FV9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16434399","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24954443","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25939779","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2FFU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FFV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4D0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4D0Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4D11","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AJN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AJO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AJP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FV9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5NDF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6EGS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	2
Details	Site: {"description":"Not glycosylated"}

Chain

Residue

Details

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site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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