6EAQ

Glycosylated FCGR3B / CD16b in complex with afucosylated IgG1 Fc

Summary for 6EAQ

Entry DOI	10.2210/pdb6eaq/pdb
Descriptor	Immunoglobulin gamma-1 heavy chain, Low affinity immunoglobulin gamma Fc region receptor III-B, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	glycosylation, glycoprotein, igg1 fc, cd16b, fcgr3b, immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	73603.13
Authors	Roberts, J.T.,Barb, A.W. (deposition date: 2018-08-03, release date: 2018-11-07, Last modification date: 2023-10-11)
Primary citation	Roberts, J.T.,Barb, A.W. A single amino acid distorts the Fc gamma receptor IIIb/CD16b structure upon binding immunoglobulin G1 and reduces affinity relative to CD16a. J. Biol. Chem., 293:19899-19908, 2018 Cited by PubMed: 30361439 DOI: 10.1074/jbc.RA118.005273 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.22 Å)

Structure validation