6EAQ
Glycosylated FCGR3B / CD16b in complex with afucosylated IgG1 Fc
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Immunoglobulin gamma-1 heavy chain | polymer | 220 | 24814.1 | 2 | UniProt (P0DOX5) Pfam (PF07654) | Homo sapiens (Human) | Immunoglobulin gamma-1 heavy chain NIE |
| 2 | C (C) | Low affinity immunoglobulin gamma Fc region receptor III-B | polymer | 175 | 20046.4 | 1 | UniProt (O75015) Pfam (PF13895) | Homo sapiens (Human) | Fc-gamma RIII-beta,FcRIIIb,FcR-10,IgG Fc receptor III-1 |
| 3 | D (D) | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1276.2 | 1 | In PDB GlyTouCan (G28663KH) | |||
| 4 | E (E) | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1479.3 | 1 | In PDB GlyTouCan (G89993FE) | |||
| 5 | F, G (F, G) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 6 | H, I, J (A, B, C) | water | water | 18.0 | 349 | Chemie (HOH) |
Sequence modifications
C: 1 - 175 (UniProt: O75015)
| PDB | External Database | Details |
|---|---|---|
| Gln 38 | Asn 56 | engineered mutation |
| Gln 64 | Asn 82 | engineered mutation |
| Gln 74 | Asn 92 | engineered mutation |
| Gln 169 | Asn 187 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 69674.5 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 3928.6 | |
| All* | Total formula weight | 73603.1 |
