6EAQ

Glycosylated FCGR3B / CD16b in complex with afucosylated IgG1 Fc

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Immunoglobulin gamma-1 heavy chain	polymer	220	24814.1	2	UniProt (P0DOX5) Pfam (PF07654) In PDB	Homo sapiens (Human)	Immunoglobulin gamma-1 heavy chain NIE
2	C	Low affinity immunoglobulin gamma Fc region receptor III-B	polymer	175	20046.4	1	UniProt (O75015) Pfam (PF13895) In PDB	Homo sapiens (Human)	Fc-gamma RIII-beta,FcRIIIb,FcR-10,IgG Fc receptor III-1
3	D	beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1276.2	1	In PDB GlyTouCan (G28663KH)
4	E	beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1479.3	1	In PDB GlyTouCan (G89993FE)
5	F, G	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G15407YE)
6		water	water		18.0	349	Chemie (HOH)

Sequence modifications

C: 1 - 175 (UniProt: O75015)

PDB	External Database	Details
Gln 38	Asn 56	engineered mutation
Gln 64	Asn 82	engineered mutation
Gln 74	Asn 92	engineered mutation
Gln 169	Asn 187	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	69674.5
Branched	Number of molecules	4
	Total formula weight	3928.6
All*	Total formula weight	73603.1

*Water molecules are not included.