6E3S
Crystal Structure of the Heterodimeric HIF-2 Complex with Antagonist PT2385
Summary for 6E3S
Entry DOI | 10.2210/pdb6e3s/pdb |
Descriptor | Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, 3-{[(1S)-2,2-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl]oxy}-5-fluorobenzonitrile (3 entities in total) |
Functional Keywords | complex, antagonist, transcription factor, transcription-transcription inhibitor complex, transcription/transcription inhibitor |
Biological source | Mus musculus (Mouse) More |
Total number of polymer chains | 2 |
Total formula weight | 85977.69 |
Authors | Wu, D.,Su, X.,Lu, J.,Li, S.,Hood, B.,Vasile, S.,Potluri, N.,Diao, X.,Kim, Y.,Khorasanizadeh, S.,Rastinejad, F. (deposition date: 2018-07-15, release date: 2019-02-13, Last modification date: 2023-10-11) |
Primary citation | Wu, D.,Su, X.,Lu, J.,Li, S.,Hood, B.L.,Vasile, S.,Potluri, N.,Diao, X.,Kim, Y.,Khorasanizadeh, S.,Rastinejad, F. Bidirectional modulation of HIF-2 activity through chemical ligands. Nat. Chem. Biol., 15:367-376, 2019 Cited by PubMed: 30804532DOI: 10.1038/s41589-019-0234-5 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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