6E3S

Crystal Structure of the Heterodimeric HIF-2 Complex with Antagonist PT2385

6E3S の概要

• エントリーDOI: 10.2210/pdb6e3s/pdb
• 分子名称: Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, 3-{[(1S)-2,2-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl]oxy}-5-fluorobenzonitrile (3 entities in total)
• 機能のキーワード: complex, antagonist, transcription factor, transcription-transcription inhibitor complex, transcription/transcription inhibitor
• 由来する生物種: Mus musculus (Mouse); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 85977.69

構造登録者

Wu, D.,Su, X.,Lu, J.,Li, S.,Hood, B.,Vasile, S.,Potluri, N.,Diao, X.,Kim, Y.,Khorasanizadeh, S.,Rastinejad, F. (登録日: 2018-07-15, 公開日: 2019-02-13, 最終更新日: 2023-10-11)

• 主引用文献: Wu, D.,Su, X.,Lu, J.,Li, S.,Hood, B.L.,Vasile, S.,Potluri, N.,Diao, X.,Kim, Y.,Khorasanizadeh, S.,Rastinejad, F.; Bidirectional modulation of HIF-2 activity through chemical ligands.; Nat. Chem. Biol., 15:367-376, 2019; PubMed: 30804532; DOI: 10.1038/s41589-019-0234-5

実験手法

X-RAY DIFFRACTION (3 Å)