6E2P

Structure of human JAK2 FERM/SH2 in complex with Leptin Receptor

Summary for 6E2P

• Entry DOI: 10.2210/pdb6e2p/pdb
• Descriptor: Tyrosine-protein kinase JAK2, Leptin receptor, SULFATE ION, ... (4 entities in total)
• Functional Keywords: cytokine receptor, leptin, signal transduction, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 129104.43

Authors

Ferrao, R.,Lupardus, P.J.,Wallweber, H.J.A. (deposition date: 2018-07-11, release date: 2018-08-08, Last modification date: 2023-10-11)

• Primary citation: Ferrao, R.D.,Wallweber, H.,Lupardus, P.J.; Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation.; Elife, 7:-, 2018; PubMed: 30044226; DOI: 10.7554/eLife.38089

Experimental method

X-RAY DIFFRACTION (2.83 Å)