6E2P
Structure of human JAK2 FERM/SH2 in complex with Leptin Receptor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosine-protein kinase JAK2 | polymer | 484 | 55919.6 | 2 | UniProt (O60674) Pfam (PF18379) Pfam (PF18377) Pfam (PF17887) Pfam (PF21990) | Homo sapiens (Human) | Janus kinase 2, JAK-2 |
| 2 | C, D (C, D) | Leptin receptor | polymer | 75 | 8584.6 | 2 | UniProt (P48357) | Homo sapiens (Human) | LEPR, LEP-R, HuB219, OB receptor, OB-R |
| 3 | E (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 27 | Chemie (HOH) |
Sequence modifications
A, B: 36 - 514 (UniProt: O60674)
C, D: 863 - 933 (UniProt: P48357)
| PDB | External Database | Details |
|---|---|---|
| Gly 34 | - | expression tag |
| Ser 35 | - | expression tag |
| Gly 515 | - | expression tag |
| Asn 516 | - | expression tag |
| Ser 517 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 862 | - | expression tag |
| Gly 934 | - | expression tag |
| Asn 935 | - | expression tag |
| Ser 936 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 129008.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 96.1 | |
| All* | Total formula weight | 129104.4 |
