6E2P

Structure of human JAK2 FERM/SH2 in complex with Leptin Receptor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0005856	cellular_component	cytoskeleton
A	0006468	biological_process	protein phosphorylation
A	0016020	cellular_component	membrane
A	0035556	biological_process	intracellular signal transduction
A	0042393	molecular_function	histone binding
B	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
B	0005524	molecular_function	ATP binding
B	0005856	cellular_component	cytoskeleton
B	0006468	biological_process	protein phosphorylation
B	0016020	cellular_component	membrane
B	0035556	biological_process	intracellular signal transduction
B	0042393	molecular_function	histone binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue SO4 A 601

Chain	Residue
A	MET406
A	ARG426
A	PRO429

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
C	SER882
D	SER882
A	LYS450
A	LYS504
B	LEU352
B	GLU442
B	LYS450
B	LYS504

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000250|UniProtKB:Q62120

Chain	Residue	Details
A	TYR119
B	TYR119

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site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q62120

Chain	Residue	Details
A	TYR372
A	TYR373
B	TYR372
B	TYR373

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