6E2P

Structure of human JAK2 FERM/SH2 in complex with Leptin Receptor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
A	0016020	cellular_component	membrane
A	0035556	biological_process	intracellular signal transduction
A	0042393	molecular_function	histone binding
B	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
B	0016020	cellular_component	membrane
B	0035556	biological_process	intracellular signal transduction
B	0042393	molecular_function	histone binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue SO4 A 601

Chain	Residue
A	MET406
A	ARG426
A	PRO429

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	162
Details	Domain: {"description":"SH2; atypical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00191","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	8
Details	Site: {"description":"Breakpoint for translocation to form PCM1-JAK2 fusion protein"}

Chain

Residue

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"UniProtKB","id":"Q62120","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q62120","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	16
Details	Motif: {"description":"Box 1 motif"}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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